| S5026 |
Irinotecan hydrochloride |
Irinotecan (CPT-11, (+)-Irinotecan) hydrochloride is an inhibitor of Topoisomerase I (Topo I) that exhibits cytotoxicity in LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
Selective |
|
| S8999 |
Exatecan Mesylate |
Exatecan Mesylate (DX-8951f) is a water-soluble and non-pro-drug analog of camptothecin and shows significant topoisomerase I inhibition with IC50 of 0.975 μg/ml. |
Selective |
|
| S9321 |
Topotecan |
Topotecan(NSC609699,Nogitecan,SKFS 104864A) is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. |
Selective |
|
| S5111 |
7-Ethylcamptothecin |
7-Ethyl Camptothecin is an anti-cancer chemical that exhibits a strong activity against various murine tumors through Topo I (topoisomerase) inhibition. |
Selective |
|
| S3898 |
Hydroxy Camptothecine |
Hydroxy Camptothecine (10-Hydroxycamptothecin, Hydroxycamptothecine) is a cell-permeable powerful DNA topoisomerase I inhibitor. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. |
Selective |
|
| S6747 |
SW-044248 |
SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. |
Selective |
|
| S0093 |
Genz-644282 |
Genz-644282 is a non-camptothecin topoisomerase I (Topo I) inhibitor that demonstrates potent cytotoxic activity with a median IC50 of 1.2 nM (range 0.2 nM-21.9 nM). Genz-644282 can be used in cancer research.The solubility of this product is not good, please choose carefully for cell experiments! |
Selective |
Topo I, IC50: 1.2 nM |
| S1231 |
Topotecan HCl |
Topotecan HCl is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis. |
Selective |
Topo I (MCF-7 Luc cells), IC50: 13 nM; Topo I (DU-145 Luc cells), IC50: 2 nM |
| S1288 |
Camptothecin (CPT) |
Camptothecin (CPT) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2. |
Selective |
Topo I, IC50: 0.68 μM |
| S3603 |
Betulinic acid |
Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. It's reported that Betulinic acid acts as a new activator of NF-κB.Phase 1/2. |
Selective |
Eukaryotic topoisomerase I, IC50: 5 μM |
| S6631 |
Belotecan (CKD-602) hydrochloride |
Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor. |
Selective |
|
| S4908 |
SN-38 |
SN-38 (NK012) is an active metabolite of CPT-11, inhibits DNA topoisomerase I, DNA synthesis and causes frequent DNA single-strand breaks. SN-38 induces autophagy. |
Selective |
|
| S2288 |
Rubitecan |
Rubitecan (9-NC, 9-Nitro-camptothecin, Partaject Orathecin, Partaject rubitecan, RFS 2000) is a topoisomerase I inhibitor extracted from the bark and leaves of the Camptotheca acuminata tree, which is native to China. Rubitecan is an oral camptothecin with antitumour activity. |
Selective |
|
| S1198 |
Irinotecan |
Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively. |
Selective |
|
| S2217 |
Irinotecan HCl Trihydrate |
Irinotecan HCl Trihydrate is a hydrochloride trihydrate of irinotecan (Camptosar, Campto, CPT-11) which is a topoisomerase I inhibitor with IC50 of 15.8 and 5.17 μM for LoVo cells and HT-29 cells, respectively. |
Selective |
|
| S2653 |
9-amino-CPT (9-Aminocamptothecin) |
9-amino-CPT (9-Aminocamptothecin, 9-AC, Aminocamptothecin, 9-amino-20(S)-camptothecin) is a Topoisomerase I inhibitor with potent anticancer activities. 9-amino-CPT (9-Aminocamptothecin) is an active, water-insoluble derivative of camptothecin. |
Selective |
|
| S7261 |
Beta-Lapachone |
Beta-Lapachone (β-Lapachone, ARQ-501) is a selective DNA topoisomerase I inhibitor, exhibiting no inhibitory activities against DNA topoisomerase II or ligase. Phase 2. |
Selective |
|
| S2423 |
(S)-10-Hydroxycamptothecin |
(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor with potent anti-tumor activity. |
Selective |
|
| S2271 |
Berberine chloride (NSC 646666) |
Berberine chloride (NSC 646666, Natural Yellow 18) is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation |
Pan |
|
| S1327 |
Ellagic acid |
Ellagic acid (Elagostasine, Gallogen) has antiproliferative and antioxidant property. |
Pan |
|
